{"title":"人类遗传学与COVID-19感染易感性的关系","authors":"Preetinder Kaur, P. Kaur","doi":"10.52679/TABCJ.2020.0007","DOIUrl":null,"url":null,"abstract":"Recent studies have shown that the progression of SARS-CoV-2 is associated with human genetic factors. Many patients have shown diverse clinical symptoms based on their age, sex, ABO blood type, underlying medical conditions, HLA system, and viral variants found in their samples. SARS-CoV-2 is considered more transmissible with higher morbidity rates as compared to the previous SARS outbreak. Several case studies have supported the direct relation of cardiovascular and pulmonary fatalities related to ACE2 polymorphisms during COVID-19 infection. SARS-CoV-2 mutants and human genome polymorphisms are vital predictive markers in finding a cure for this pandemic. This review focuses on some of the critical genetic factors of the host that affect the array of immunological responses as a result of COVID-19 infection among individuals.","PeriodicalId":424992,"journal":{"name":"The Applied Biology & Chemistry Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship between human genetics and susceptibility to COVID-19 infection\",\"authors\":\"Preetinder Kaur, P. Kaur\",\"doi\":\"10.52679/TABCJ.2020.0007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Recent studies have shown that the progression of SARS-CoV-2 is associated with human genetic factors. Many patients have shown diverse clinical symptoms based on their age, sex, ABO blood type, underlying medical conditions, HLA system, and viral variants found in their samples. SARS-CoV-2 is considered more transmissible with higher morbidity rates as compared to the previous SARS outbreak. Several case studies have supported the direct relation of cardiovascular and pulmonary fatalities related to ACE2 polymorphisms during COVID-19 infection. SARS-CoV-2 mutants and human genome polymorphisms are vital predictive markers in finding a cure for this pandemic. This review focuses on some of the critical genetic factors of the host that affect the array of immunological responses as a result of COVID-19 infection among individuals.\",\"PeriodicalId\":424992,\"journal\":{\"name\":\"The Applied Biology & Chemistry Journal\",\"volume\":\"8 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Applied Biology & Chemistry Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.52679/TABCJ.2020.0007\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Applied Biology & Chemistry Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52679/TABCJ.2020.0007","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Relationship between human genetics and susceptibility to COVID-19 infection
Recent studies have shown that the progression of SARS-CoV-2 is associated with human genetic factors. Many patients have shown diverse clinical symptoms based on their age, sex, ABO blood type, underlying medical conditions, HLA system, and viral variants found in their samples. SARS-CoV-2 is considered more transmissible with higher morbidity rates as compared to the previous SARS outbreak. Several case studies have supported the direct relation of cardiovascular and pulmonary fatalities related to ACE2 polymorphisms during COVID-19 infection. SARS-CoV-2 mutants and human genome polymorphisms are vital predictive markers in finding a cure for this pandemic. This review focuses on some of the critical genetic factors of the host that affect the array of immunological responses as a result of COVID-19 infection among individuals.
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