{"title":"不同年龄组成年实验室大鼠溶血性贫血后的骨髓和脾脏形态学。","authors":"J Berger","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We induced toxic-haemolytic events in 8, 11 and 29-w-old rats after single dose of nitrobenzene, 3-chloro-4-benzyloxyphenacetic acid and phenacetin administered orally. Large individual variability of haematological changes in rat marrow and spleen morphology was found. The use of groups of laboratory rats of different age significantly modified reactions in characteristics investigated but common simple age-related changes were not clearly demonstrated.</p>","PeriodicalId":75853,"journal":{"name":"Folia haematologica (Leipzig, Germany : 1928)","volume":"117 1","pages":"1-5"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bone marrow and spleen morphology following haemolytic anaemia in adult laboratory rats of various age groups.\",\"authors\":\"J Berger\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We induced toxic-haemolytic events in 8, 11 and 29-w-old rats after single dose of nitrobenzene, 3-chloro-4-benzyloxyphenacetic acid and phenacetin administered orally. Large individual variability of haematological changes in rat marrow and spleen morphology was found. The use of groups of laboratory rats of different age significantly modified reactions in characteristics investigated but common simple age-related changes were not clearly demonstrated.</p>\",\"PeriodicalId\":75853,\"journal\":{\"name\":\"Folia haematologica (Leipzig, Germany : 1928)\",\"volume\":\"117 1\",\"pages\":\"1-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Folia haematologica (Leipzig, Germany : 1928)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Folia haematologica (Leipzig, Germany : 1928)","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Bone marrow and spleen morphology following haemolytic anaemia in adult laboratory rats of various age groups.
We induced toxic-haemolytic events in 8, 11 and 29-w-old rats after single dose of nitrobenzene, 3-chloro-4-benzyloxyphenacetic acid and phenacetin administered orally. Large individual variability of haematological changes in rat marrow and spleen morphology was found. The use of groups of laboratory rats of different age significantly modified reactions in characteristics investigated but common simple age-related changes were not clearly demonstrated.
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