雄激素治疗作为改善卵巢衰老女性生殖预后的一种可能性

Ana Karina Bartmann , Anderson Sanches de Melo , Victor César de Paula S. Nascimento , Thalita Souza Bertelli
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引用次数: 1

摘要

对卵巢刺激的反应是辅助生殖(AR)的关键因素。尽管近年来技术有所进步,但卵巢储备能力低的患者预后差,这是生殖医学的一个挑战。目的探讨在刺激卵巢前使用睾酮改善38岁以上女性或年轻女性低卵泡计数生殖预后的策略。材料与方法从生殖医学领域的科学文献中收集调查数据。结果和结论在体外受精周期中,在卵巢刺激前阶段使用雄激素似乎是改善38岁以上或卵巢储备功能减退患者卵母细胞控制刺激的重要工具,可以改善卵母细胞的数量和质量,提高妊娠率和活产率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tratamento com andrógenos como possibilidade de melhoria do prognóstico reprodutivo em mulheres com envelhecimento ovariano

Justification

The response to ovarian stimulation is a keyelement in assisted reproduction (AR). Despite recent advances in the techniques, patients with low ovarian reserve have poor prognosis and represent a challenge in reproductive medicine.

Objective

To propose a strategy to improve reproductive prognosis of women older than 38 years or young women with low antral follicle count, through the use of testosterone prior to ovarian stimulus.

Material and methods

Survey data from the scientific literature in the field of reproductive medicine.

Results and conclusions

The use of androgens in stages preceding ovarian stimulation in IVF cycles seems to be great tool for improving oocyte response inoocyte controlled stimulation of patients older than 38 years or with diminished ovarian reserve, improving both quantity and quality of oocytes and increasing rates of pregnancy and live‐born.

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