脂质乳剂治疗儿童三环类抗抑郁药物中毒:一项观察性队列研究

Esra Türe, F. Akın, A. Yazar, A. Kılıç
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引用次数: 0

摘要

三环抗抑郁药(TCA)中毒是最常见的儿童中毒之一,因为它便宜且容易获得。在这篇文章中,我们旨在分享静脉注射脂质乳剂(ILE)治疗的经验,以及对高剂量TCA摄入中毒病例的基本治疗步骤和治疗效果的讨论。2014年1月至2019年12月因药物中毒入院儿科急诊科的18岁以下患者;有tca暴露史的人也包括在我们的研究中。通过对6年病例的检查,确定中毒病例共619例,其中TCA中毒108例(17.4%)。21例(19.4%)有低血压、心动过速和心电图改变且对所有基本治疗步骤都难治的患者接受ILE治疗。经ILE治疗后,患者的临床、心电图及生命体征均有明显改善。对于碳酸氢钠难治性低血压、传导障碍、心律失常或QRS增宽的病例,在急诊科早期给予ILE治疗被认为可以预防潜在的心血管并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipid Emulsion Treatment in Tricyclic Antidepressant Poisoning in Children: An Observational Cohort Study
Tricyclic antidepressant (TCA) poisonings are among the most common childhood poisonings because of being cheap and readily available. In this manuscript, we aimed to share our experience with Intravenous lipid emulsions (ILE) treatment in addition to basic treatment steps and discussion of effectiveness of treatment in cases of poisoning caused by high-dose TCA intake. From the patients under 18 years of age who admitted to Pediatric Emergency Department due to drug intoxication between January 2014 and December 2019; those who had history of exposure to TCAs were included in our study. In conclusion of examination of six-year patient records, it was determined that there were a total of 619 intoxication cases and 108 (17.4%) of these were TCA poisoning. 21 (19.4%) patients who had hypotension, tachycardia and ECG changes which were refractory to all basic treatment steps were administered ILE. After ILE treatment, a marked improvement was observed in patients’ clinical and ECG findings, as well as vital signs. Early administration of ILE treatment in emergency departments for cases with hypotension, conduction disorder, dysrhythmia or widened QRS which are refractory to sodium bicarbonate is thought to prevent potential cardiovascular complications.
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