癌基因C-Ha-ras密码子12突变与胃癌患者转移及生存的相关性

Oncogene research Pub Date : 1991-01-01

G R Deng, X H Liu, J R Wang

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引用次数: 0

摘要

应用聚合酶链反应限制性分析，在27例人胃癌患者新鲜组织和细胞系中11例检测到c-Ha-ras密码子12位点突变。进一步的统计研究表明，点突变的存在与胃癌远端转移及术后患者的生存时间有关。

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Correlation of mutations of oncogene C-Ha-ras at codon 12 with metastasis and survival of gastric cancer patients.

Mutations of c-Ha-ras at codon 12 were detected from 11 out of 27 fresh tissues and cell-lines of human gastric cancer patients using PCR-restriction analysis. Further statistical investigation showed that the presence of point mutations was related to the distal metastases and the survival time of gastric cancer patients after surgical operations.

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来源期刊

Oncogene research

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