硬葡聚糖缓释口服制剂。第二部分。添加剂的影响。

Drug design and delivery Pub Date : 1990-03-01
F Alhaique, E Beltrami, F M Riccieri, E Santucci, E Touitou
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引用次数: 0

摘要

用硬葡聚糖和几种亲疏水添加剂制备的片进行体外肿胀和扩散实验表明,通过适当选择添加剂的性质和量,可以调节药物从基质中释放。制剂中的添加剂可能影响药物从剂型中释放的机制(零级、扩散、侵蚀)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Scleroglucan sustained release oral preparations. Part II. Effects of additives.

Swelling and diffusion experiments, performed in vitro with tablets prepared with scleroglucan and several hydrophilic and hydrophobic additives, indicate that it is possible to modulate drug delivery from the matrix by appropriate choice of the nature and amount of the additive. The additives in the formulations may affect the mechanisms (zero order, diffusion, erosion) involved in the release of drugs from the dosage forms.

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