EXPRESSION OF THE TYROSINE KINASE RECEPTOR (EPHA1) IN THE EUTOPIC AND ECTOPIC ENDOMETRIUM OF PATIENTS WITH DEEP INFILTRATIVE ENDOMETRIOSIS USE OF MODERN DIGITAL TECHNOLOGIES

Objective of the study is to еvaluate the expression of EphA1 in the endometrium of healthy women, in eutopic and ectopic epithelial cells in deep infiltrative endometriosis. Used materials and methods such as IHC was carried out a comparative study of EphA1 expression in eutopic and ectopic endometrium in women with endometriosis depending on the type of endometriosis and in healthy women in different phases of the menstrual cycle. Have shown for the first time that in normal endometrium, a significantly higher expression of the EphA1 receptor on the surface of glandular cells is observed in the secretory phase of the menstrual cycle, compared with the proliferative one. In the eutopic endometrium of patients with DIE, a significantly increased level of EphA1 expression was found in both the proliferative and secretory phases of menstrual cycle compared with the group without endometriosis. The highest level of expression was detected in the foci of DIE (28.0 с.u. in the proliferative and 30.5 a.u. in the secretory phases). Indeed, overexpression of the EphA1 receptor in glandular cells of the eutopic and ectopic endometrium in patients with DIE makes them a perspicuous target for the development of new technologies for diagnosis and therapy in endometriosis.