[7-乙氧基香豆素o-去乙基酶与慢性肝病纤维化]。

Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1991-01-01

J Truckenbrodt, A Müller, H Kraul, G Machnik, R Volland, M Reinhardt, A Hoffmann

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引用次数: 0

摘要

对100例慢性肝病患者进行肝活检，测定7-乙氧基香豆素o -去乙基酶(ECOD)活性作为肝单加氧酶系统的参数，并与胶原肽酶、羟脯氨酸等纤维化指标进行比较。健康肝、脂肪肝、慢性活动性肝炎(CAH)和肝硬化患者的ECOD差异有统计学意义。肝活检中ECOD与纤维化体征之间的显著相关性表明了纤维化过程的重要性。未发现ECOD与纤维化标志物之间的联系。需要进一步的研究来澄清这种差异。

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[7-ethoxycoumarin o-deethylase and fibrosis in chronic liver diseases].

In the liver biopsy of 100 patients with chronic liver diseases, the activity of 7-ethoxycoumarin O-deethylase (ECOD) was determined as a parameter of hepatic monooxygenase system and was compared with some markers of fibrosis e.g. collagen peptidase and hydroxyproline. ECOD was significantly different in healthy liver, fatty liver, chronic active hepatitis (CAH) and cirrhosis. The importance of the fibrotic process was shown by the significant correlations between ECOD and the signs of fibrosis in the liver biopsy. A connection between ECOD and the markers of fibrosis was not found. Further research is necessary to clarify this difference.

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Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR

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