P. Preda, B. Adiaconiţă, G. Crăciun, I. Mihalache, A. Boldeiu, O. Brîncoveanu, M. Maxim, E. Chiriac, M. Avram
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Chitosan-coated gold nanocomposites loading with cisplatin for potential use in cancer therapy
This paper discusses the synthesis of nanocomposites based on chitosan-coated gold nanoparticles (CS-AuNPs) and the loading with cisplatin drug (CisPt). Limited studies were performed on the evaluation of AuNPs functionalized with biopolymers and conjugated with CisPt. The loading of the CS-AuNPs with cisplatin was performed in order to obtain drugs delivery systems for cancer therapy. The obtained CS-AuNPs proved to be stable, with a slight agglomeration tendency (PI of 0.302) and a hydrodynamic diameter of 85 nm. The CisPt loading in the nanocomposites was confirmed by UV-vis spectroscopy.
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