静脉注射二氯乙酸钠溶液的制备及稳定性。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1992-01-01

P I Chu, S H Curry, T G Baumgartner, G N Henderson, P W Stacpoole

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引用次数: 0

摘要

制备了一种静脉注射用二氯乙酸钠(DCA)制剂，并进行了稳定性试验。DCA在水溶液中热不稳定。它的分解包括脱卤和氢离子的产生。在相对较低的pH值下，分解发生得相对较快，并通过加热促进。注射溶液应无菌配制，并经过滤灭菌。经无菌制备和过滤灭菌的溶液在4℃下稳定保存至少4年。

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Preparation and stability of intravenous solutions of sodium dichloroacetate (DCA).

An IV injection formulation of sodium dichloroacetate (DCA) was prepared without heat sterilization, and examined for stability. DCA is heat labile in aqueous solutions. Its decomposition involves dehalogenation and production of hydrogen ions. Decomposition occurs relatively rapidly at relatively low pH values, and is promoted by heating. Injection solutions should be prepared aseptically and sterilized by filtration. Solutions prepared aseptically and sterilized by filtration are stable stored at 4 degrees C for at least four yrs.

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Journal of parenteral science and technology : a publication of the Parenteral Drug Association

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