具有剂量控制的光动力治疗照射系统的研制

Luis Hernandez-Quintanar, S. S. Isakina, J. M. D. L. Rosa-Vázquez
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引用次数: 0

摘要

光动力疗法是一种众所周知的基于光与光敏剂药物和氧气相互作用的治疗方法。它已被用于治疗某些疾病,尤其是癌症。在实施治疗的主要问题之一是使用激光作为光源,这增加了治疗的成本。这就是为什么我们提出光动力治疗辐射系统的发展,该系统允许在630纳米光辐射应用于原生卟啉- ix治疗,使用更便宜的光源作为高功率发光二极管。此外,还提出了一种自动控制照射功率和时间的方法,以确保系统的稳定性,并在未来纳入一种算法,以确定所需的光学剂量学深度,以获得最佳的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of an irradiation system for photodynamic therapy with dosimetric control
Photodynamic therapy is a well know treatment based on the interaction of light with a photosensitizer drug and oxygen. It has been used for the treatment of certain diseases, especially cancer. One of the major problems in the implementation of the therapy is the use of lasers as light sources which increases the cost of the therapy. This is why we propose the development of photodynamic therapy irradiation system which allows the application of optical radiation at 630 nm for Protophorphyrin-IX therapy, using cheaper light sources as high power light emission diodes. Additionally, it is proposed an automatic control of power and time for the irradiation to ensure the stability of the system and also the future inclusion of an algorithm to determine the required optical dosimetry in depth to get optimal therapeutic effects.
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