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LenteraBio : Berkala Ilmiah Biologi Pub Date : 2021-11-30 DOI:10.26740/lenterabio.v11n1.p122-130

Andarista Diaz Aleydaputri, Nur Kuswanti

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摘要

糖尿病是一种代谢紊乱。研究的目的是确定马尼拉蛋白酶提取物对朗格汉斯岛的资料和糖尿病糖尿病患者的体重的影响。该研究是一项以6组进行的硬体麻醉研究(正常控制，aloksan控制，1剂量提取(28mg/kg BB)， 2剂量提取提取(562 mg/kg BB)， 3剂量提取提取(112mg/kg BB)和glibenclamide进行研究，每组4次重放。小腹糖尿病人每天服用两次树胶叶提取物14天。朗格汉斯岛的概况是通过对胰腺和先验确定的。小增体重在第0天、第7天和第14天。数据是用Anova分析的。分析表明，萃取物与p. Langerhans (p . < 0.05)和体重(p . < 0.05)之间治疗差异有影响。平均直径大小的p . Langerhans 14天后即待遇39µm (KN), 34.5µm (KA), 38.6µm (K1), 56,5µm (K2), 48,3µm (K3)和41.6µm(公斤)。而重量则为33.25 (KN)、33.75 (KA)、32 (K1)、2875 (K2)、3075 (K3)和29.50 (KG)。这种树胶提取物通过增加其直径和不匹配剂量的增稠剂对Langerhans岛的轮廓产生影响。关键词:重量;树胶叶状;糖尿病;LangerhansAbstract岛。糖尿病是一种代谢疾病。这项研究确定了朗格汉斯和糖尿病体重的简介。这个研究是一种以6个groups(正常控制、异位控制、extract dose 1 (28mg/kg BW)、extract dose 2 (562 mg/kg BW)、extract dose 3 (112mg/kg BW)和glibenclamide进行的硬性研究，表现得很好。每个都有4个复制因子。有一个诱因米粒被授予sapodilla leaf extract一天14天。简介说，兰格汉斯岛的特点是通过观察恐慌和准备，确定了它们的直径。老鼠的体重在0天、7天和14天之间增加。数据是用Anova进行分析。分析表明，extract的直径影响了Langerhans islet的直径(p< 0.05)和mice (p< 0.05)以及treatments之间的差异。islets of Langerhans直径均值》之后的14天的治疗是39 (KN) 34。5 (KA), 6 - 38 (K1) 56 . 5 (K2)、48 . 3 (K3)和41(6公斤)µms。虽然米格的重量是33.25 (KN)， 33.75 (KA)， 32 (K1)， 28.75 (K2)， 30.75 (K3)和29.50 (KG) grs。Sapodilla leaf extract影响了它们的直径和独立式服装的身体重量。关键词:身体重量;Sapodilla leaf，糖尿病患者，Langerhans岛

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Efek Ekstrak Daun Sawo Manila (Manilkara zapota L.) terhadap Profil Pulau Langerhans dan Berat Badan Mencit Diabetes

Diabetes melitus adalah penyakit gangguan metabolisme. Penelitian bertujuan mengetahui pengaruh ekstrak daun sawo manila terhadap profil pulau Langerhans dan berat badan mencit diabetes. Studi ini merupakan penelitian ekperimental menggunakan RAL dengan 6 kelompok (kontrol normal, kontrol aloksan, dosis ekstrak 1 (28mg/kg BB), dosis ekstrak 2 (56mg/kg BB), dosis ekstrak 3 (112mg/kg BB) dan glibenclamide), masing-masing dengan 4 ulangan. Mencit diabetes induksi aloksan diberi ekstrak daun sawo dua kali sehari selama 14 hari. Profil pulau Langerhans ditentukan berdasarkan diameternya melalui pengamatan preparat-HE pankreas. Berat badan mencit ditimbang pada hari ke 0, ke 7 dan ke 14. Data dianalisis menggunakan Anova. Hasil analisis menunjukkan ekstrak berpengaruh terhadap diameter p. Langerhans (p<0,05) dan berat badan (p<0,05) dengan perbedaan antar perlakuan. Rerata diameter p. Langerhans setelah 14 hari perlakuan yaitu sebesar 39 µm (KN), 34,5 µm (KA), 38,6 µm (K1), 56,5 µm (K2), 48,3 µm (K3) dan 41,6 µm (KG). Sedangkan berat badan mencit yaitu sebesar 33,25 (KN), 33,75 (KA), 32 (K1), 28,75 (K2), 30,75 (K3) dan 29,50 (KG). Ekstrak daun sawo berpengaruh terhadap profil pulau Langerhans dengan memperbesar diameternya dan terhadap berat badan mencit dengan tidak sejalan dosis. Kata kunci: Berat badan; Daun Sawo; Diabetes; Pulau Langerhans Abstract. Diabetes mellitus is a metabolic disorder disease. The study was to determine effect of sapodilla leaf extract on the profile of the islets of Langerhans and body weight of diabetic mice. This study is experimental study using RAL with 6 groups (normal control, alloxan control, extract dose 1 (28mg/kg BW), extract dose 2 (56mg/kg BW), extract dose 3 (112mg/kg BW) and glibenclamide), respectively. each with 4 replicates. Alloxan induced mice were given sapodilla leaf extract twice a day for 14 days. The profile the islets of Langerhans was determined based on their diameter by observing pancreatic HE-preparations. The BW of the mice was measured on 0, 7 and 14 days. Data were analyzed using Anova. The analysis showed that the extract had an effect on the diameter of the islets Langerhans (p< 0,05) and BW of mice (p< 0,05) with differences between treatments. The mean diameter of the islets of Langerhans after 14 days of treatment was 39 (KN), 34.5 (KA), 38.6 (K1), 56.5 (K2), 48.3 (K3) and 41.6 (KG) µms. While the weight of the mice were 33.25 (KN), 33.75 (KA), 32 (K1), 28.75 (K2), 30.75 (K3) and 29.50 (KG) grs. Sapodilla leaf extract affected the profile of Langerhans islands by increasing their diameter and on the body weight of mice in dose independent manner. Kata kunci: Bodyweight; Sapodilla leaf, Diabetic, Langerhans island

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LenteraBio : Berkala Ilmiah Biologi

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