用于测量密闭空间中细胞牵引力的悬臂阵列

2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Pub Date : 2017-06-18 DOI:10.1109/TRANSDUCERS.2017.7994020

K. H. Shoji, Kenei Matsudaira, T. Tsukagoshi, Thanh-Vinh Nguyen, K. Noda, I. Shimoyama

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引用次数: 0

摘要

本文报道了一种传感器，可以直接测量在密闭空间中移动细胞产生的牵引力。该传感器由一组由pluronic-F127图案包围的微型压阻悬臂组成。当细胞与pluronic-F127的粘附性较差时，该图案允许细胞向悬臂阵列的自对准和定向迁移。我们的方法能够定量地评估细胞在控制迁移方向下的牵引力。

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Cantilever array for measuring traction forces of cells in a confined space

This paper reports a sensor to directly measure the traction forces generated by migrating cells in a confined space. The sensor consists of an array of miniaturized piezoresistive cantilevers which are surrounded by a pluronic-F127 pattern. The pattern allows the self-alignment and directional migration of the cells to the cantilever array as the adhesion of cells to pluronic-F127 is poor. Our method enables the quantitative evaluation of the traction forces of cells with controlled migrating direction.

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2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)

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