精神障碍与子宫内暴露于合成激素之间联系的证据:一段漫长而关键的历史

M. Soyer-Gobillard, L. Gaspari, C. Sultan
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引用次数: 1

摘要

己烯雌酚对子宫内暴露的儿童的身体影响早已被认识到。尽管动物研究提供了躯体和行为障碍的证据,但精神疾病的情况并非如此。最近的研究报告了合成雌激素对胎儿大脑的精神影响,如精神分裂症、双相情感障碍、抑郁症、饮食失调、自杀、自杀未遂。最近,巴黎圣安妮医院(St. Anne’s Hospital, Paris)的一个研究小组(Krebs教授,Kebir博士)展示了DES对大脑的表观遗传机制,两个在神经发育中起重要作用的基因的特异性甲基化:adamts9(控制生殖器官和胎儿中枢神经系统的形成)和ZFP 57基因被认为与精神病有关。在避孕和激素替代疗法中使用的黄体酮已知会影响成人的大脑,但在我们最近的一篇论文之前,没有关于儿童子宫内暴露后黄体酮影响的数据。临床数据收集自1934名患者协会HHORAGES队列的儿童。我们的数据显示,在子宫内暴露于黄体酮的儿童中存在躯体疾病和精神疾病的急剧增加。这些精神障碍与接触合成雌激素引起的病理相同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evidence for Link Between Mental Disorders and in Utero Exposure to Synthetic Hormones: A Long and Crucial History
Somatic effects of diethylstilbestrol on children exposed in utero have long been recognized. This is not the case for psychiatric disorders, although animal studies provide evidence of somatic and behavioral disorders. Recent studies have reported psychiatric effects of synthetic estrogens on the brain of children exposed in utero as schizophrenia, bipolar disorders, depression, eating disorders, suicides, suicide attempts. Recently, a team of St. Anne’s Hospital, Paris (Prof. Krebs, Dr. Kebir) demonstrated the epigenetic mechanism of DES effect on the brain, a specific methylation of two genes playing important roles in neurodevelopment: the ADAM TS9 (control of the formation of reproductive organs and of the fetus’s CNS) and the ZFP 57 gene suggested to be associated with psychosis. Progestins used in contraception and in hormone replacement therapy are known to affect the adult brain, but no data on children existed before our recent paper on their effects after in utero exposure. Clinical data were collected from 1934 children of the Association of Patients HHORAGES cohort. Our data show the presence of somatic disorders and a drastic increase of psychiatric disorders among children in utero exposed to progestins. These mental disorders are the same as pathologies provoked by exposure to synthetic estrogens.
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