丙戊酸对实验性蛛网膜下腔出血模型血管痉挛的影响

C. O. Cakir, A. Koçak
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引用次数: 0

摘要

背景与目的:本研究的主要目的是观察实验性SAH模型动脉壁的改变,探讨丙戊酸对基底动脉和脑组织的影响,以预防这些改变和血管痉挛。材料与方法:选用新西兰兔24只。动物随机分为对照组(C)、蛛网膜下腔出血组(SAH)和丙戊酸组(VPA)。所有动物均行大池穿刺。除对照组外,非肝素化自体血均发生SAH。治疗组腹腔注射丙戊酸100 mg/kg。所有动物在48小时后被献祭。所有的实验和外科手术都得到了İnönü大学动物研究委员会的批准。结果:我们预期SAH组动脉管腔面积会小于对照组。经过统计计算,我们发现我们的期望与我们的发现相似,SAH组动脉管腔最小,对照组动脉管腔最大。这些差异具有统计学意义。结论:丙戊酸可通过预防SAH引起的动脉壁改变来预防血管痉挛。它可能对SAH引起的血管痉挛患者有临床益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Valproic Acid on Vasospasm at Experimental Subarachnoidal Hemorrhage Model
Background and Purpose: The main purpose of our study was to observe the changes occuring on arterial walls due to experimental SAH model and to investigate the effects of valproic acid on the basilar artery and brain tissues to prevent these changes and vasospasm. Material and Method: We used 24 New Zeland rabbits. Animals were randomly divided into three groups as control (C), subarachnoidal hemorrhage (SAH) and valproic acid (VPA) groups. Cisterna magna puncture was done to all animals. SAH occured by giving non heparinised autologous blood except control group. 100 mg/kg of Valproic acid was given intra peritoneally to treatment group. All animals were sacrified after 48 hours. All experimental and surgical procedures were approved by İnönü University Animal Research Comittee. Results: Our expectation was the arterial lumen area of SAH group will be smaller than control group. After statistical calculations we found that our expectation was similiar with our findings that the smallest artery lumen was seen in SAH group and the largest artery lumen was seen in control group. These differences were statistically significant. Conclusion: Our findings showed that Valproic acid can prevent vasospasm by preventing arterial wall changes induced by SAH. It may be clinically beneficial at patients suffering from vasospasm due to SAH.
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