食物中胆碱含量对颅脑损伤机体生命参数动态影响的模拟

T. Dubovaya, V.V. Pavelyev
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引用次数: 0

摘要

本文采用数学建模的方法,对反映食物中胆碱含量与数量关系的某些指标之间的关系进行了研究,研究了$\ α $7烟碱乙酰胆碱受体在动物大脑及摄食和饮水质量体中的表达水平。在此基础上,提出了一种优化使用胆碱过量饮食的方法,以更充分地维持脑损伤时机体的认知功能和其他状态指标。开发的模型允许获得定性的新信息,这些信息有助于解释数据,并加深对所收到的上述过程的关系机制的认识。该结果可用于实验动物模型和临床中使用胆碱纠正脑部疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Simulation of the Influence of Amount of Choline in Food on Dynamics of the Life Parameters of the Organism with Craniocerebral Injury
With a method of mathematical modeling the relationship of certain indicators reflecting the relationship of content quantity of choline in food, the expression level of $\alpha$7 nicotinic acetylcholine receptors in the brain, as well as mass bodies of animals their intake of food and water has been studied. Based on the received model a method for optimizing the use of choline-excess diet to more fully maintain cognitive functions of the brain and other indicators of the State of the organism in brain injury has developed. The developed model allowed obtaining qualitatively new information useful to interpret the data and to deepen notions about the mechanisms of the relationship of the above processes received. The results can be used for correction of brain disorders by using choline in experimental animal models and in the clinic.
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