R. Thewes, C. Paulus, M. Schienle, F. Hofmann, A. Frey, R. Brederlow, P. Schindler-Bauer, M. Augustyniak, M. Atzesberger, B. Holzapfl, M. Jenkner, B. Eversmann, G. Beer, M. Fritz, T. Haneder, H. Hanke
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Integrated circuits for the biology-to-silicon interface
An overview is given of CMOS-based sensor and actuator chips for in-vitro applications in the biotechnology area. We address the challenges and the potential of the combination of solid-state circuits with the wet world of bio molecules and living cells. Basic biological operating principles, market considerations, extended CMOS processing issues, and concrete circuit examples are discussed.