Effect of Treatment With Direct Acting Antivirals on Glucose and Lipid Metabolism in Egyptian Patients With Chronic Hepatitis C

The aim of this study is to evaluate the effect of the different direct acting antivirals regimens available for treatment of Egyptian patients with chronic hepatitis post hepatitis C virus (HCV) infection as regards the changes in blood glucose and lipid metabolism. This is prospective observational study conducted on 45 naïve patients with chronic hepatitis C infection. All the patients were subjected to routine; laboratory investigation, fasting serum insulin, lipid profile and abdominal ultrasound before receiving direct acting antivirals (DAAs) and at 12 weeks after end of treatment at sustained virologcal response (SVR) 12. A significant increase of cholesterol, triglycerides and HDL at SVR 12 (P-value <0.001, 0.007 and <0.001) was observed. significant decrease in both ALT & AST p.value 0.001 for both the same for total bilirubin p.value 0.001, While serum albumin increased p.value 0.012 were also found at SVR 12. There was a significant decrease of insulin, fasting blood glucose FBG, 2 hours postprandial glucose and the HOMA IR 12 weeks after treatment at SVR 12 (P-value =0.010, 0.006 , <0.;001 and 0.002, respectively). Fibrosis index 4 (FIB-4) showed significant improvement (P-value <0.001).