导论章:生物碱-它们在自然界和人类生活中的重要性

Joanna Kurek
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引用次数: 50

摘要

自然界中有许多天然化合物。在碳水化合物、脂类、蛋白质、氨基酸、花青素、类黄酮和类固醇等许多种类的天然有机化合物中,生物碱似乎很特别。是什么让他们与众不同?它们来源于氨基酸,可以被植物和一些动物合成为次生代谢产物。这些化合物在生物体中起着重要作用。生物碱一直以来对人类都是极其重要的,除了它们是次生代谢产物,还有什么能说明它们是无用的呢?生物碱在非常小的剂量下对动物和人体有机体显示出很强的生物效应。生物碱不仅存在于人类日常生活的食品和饮料中,而且还作为兴奋剂存在。它们具有抗炎、抗癌、镇痛、局部麻醉和镇痛、神经药理学、抗菌、抗真菌和许多其他活性。生物碱可作为膳食成分、补充剂和药物,在医学和人类生活中的其他应用中发挥重要作用。生物碱也是有机合成中寻找可能比母体化合物具有更好生物活性的新半合成和合成化合物的重要化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Introductory Chapter: Alkaloids - Their Importance in Nature and for Human Life
In nature there are many natural compounds. From among many classes of naturally occurring organic compounds such as carbohydrates, lipids, proteins, amino acids, anthocyanins, flavonoids, and steroids, the one that seems to be quite special is alkaloids. What makes them special? They derived from amino acids and can be synthetized as secondary metabolites by plants and some animals. These compounds play an important role in living organisms. Alkaloids occurred to be extremely important for human beings for ages, besides they are secondary metabolites, what could suggest that they are useless. Alkaloids showed strong biological effects on animal and human organisms in very small doses. Alkaloids are present not only in human daily life in food and drinks but also as stimulant drugs. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds.
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