{"title":"蛋白质碘化试剂n -丁二酰-3-碘-[125I]苯甲酸酯的简便合成","authors":"A. Freud, A. Canfi, M. Zafran","doi":"10.1016/0883-2897(92)90105-8","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 6","pages":"Pages 703-704"},"PeriodicalIF":0.0000,"publicationDate":"1992-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90105-8","citationCount":"1","resultStr":"{\"title\":\"A convenient synthesis of N-succinimidyl-3-iodo-[125I]benzoate, a reagent for protein iodination\",\"authors\":\"A. Freud, A. Canfi, M. Zafran\",\"doi\":\"10.1016/0883-2897(92)90105-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":14328,\"journal\":{\"name\":\"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology\",\"volume\":\"19 6\",\"pages\":\"Pages 703-704\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0883-2897(92)90105-8\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0883289792901058\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0883289792901058","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
建立了一种简便的合成n -丁二酰-3-碘-[125I]苯甲酸酯的方法。这一过程包括合成氯汞苯甲酸,与n -羟基琥珀酰亚胺(NHS)进行酯化反应,并在氧化剂的存在下将汞部分与放射性碘交换。将所得产物与人血清白蛋白吸附,并与氯胺- t (Ch-T)放射性碘化蛋白进行稳定性比较。结果表明,放射性标记蛋白在较长时间内稳定,脱碘率明显降低。