不同人类基因组特征的核小体定位决定因素

2016 9th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI) Pub Date : 2016-10-01 DOI:10.1109/CISP-BMEI.2016.7853006

Yanning Cai

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引用次数: 0

摘要

核小体是染色质的基本单位，在基因组的包装过程中起着重要作用。我们发现了人CD4 +细胞不同基因间核小体定位的特点。结果发现，大约20个因素的线性组合可以解释每个基因组的核小体定位。在这些线性组合中，组蛋白修饰和6个DNA序列的特性是共享的。其他因素则有所不同。本研究具有较高的分辨率，大大简化了预测和了解人类CD4 +细胞不同基因组特征的手段，提供了更准确的核小体占用率。

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Nucleosome positioning determinants for distinct human genomic features

Nucleosome which is the basic chromatin unit plays an important role in the genome packaging. We found the characteristics of nucleosome positioning among different genes of the human CD4 + cells. It was found that a linear combination of approximately 20 factors explaining the nucleosome positioning of each genome. In these linear combinations, a histone modification and the properties of the 6 DNA sequences are shared. Other factors are different. This study has a high resolution, which greatly simplifies the means to predict and understand the different genomic features in human CD4 + cells, providing a more accurate nucleosome occupancy.

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2016 9th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics (CISP-BMEI)

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