肾小球血管紧张素II受体亚型的特征。

Receptor Pub Date : 1992-01-01

G Gauquelin, R Garcia

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摘要

放射配体受体结合技术鉴定了大鼠肾小球膜中的两种血管紧张素II (ANG II)受体亚型。通过使用两种高特异性的非肽ANG II拮抗剂:Losartan (DuP 753)，这是AT1亚型特异性的，PD 123319，这是AT2亚型特异性的。肾小球膜上的大多数ANG II受体对应于AT1亚型。

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Characterization of glomerular angiotensin II receptor subtypes.

Radioligand-receptor binding techniques identified two angiotensin II (ANG II) receptor subtypes in rat renal glomerular membranes. This characterization was made possible by employing two highly-specific nonpeptide ANG II antagonists: Losartan (DuP 753), which is specific to the AT1 subtype, and PD 123319, which is specific to the AT2 subtype. The majority of ANG II receptors in glomerular membranes corresponded to the AT1 subtype.

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