HNF1A基因多态性对伊拉克妇女多囊卵巢综合征风险的影响

Elham Ahmed Toama, Hamssa Ahmed Jasim
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引用次数: 0

摘要

多囊卵巢综合征(PCOS)是女性不孕的最常见原因之一。临床特征引起的高水平雄激素,少月经,多囊卵巢形态是必要的诊断。本研究旨在发现伊拉克妇女HNF1A基因多态性与多囊卵巢综合征风险之间的关系。该研究包括100名巴格达的伊拉克妇女(15-35岁);患者分为三组。第一组为接受二甲双胍治疗的患者,第二组为未接受二甲双胍治疗的患者,第三组为健康者。提取DNA, RT-PCR检测HNF1A基因分型多态性(rs1169288)。AA基因型在对照组中出现频率较高(p=0.001), CC基因型在患者中出现频率较高(p= 0.0001)。关键词:多囊卵巢综合征(PCOS),遗传多态性,hnf1a蛋白,葡萄糖和脂质谱
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effect of HNF1A Gene Polymorphism on the Risk of Polycystic Ovary Syndrome in a Sample of Iraqi Women
Polycystic ovary syndrome (PCOS) is one of the most common causes of female infertility. Clinical features caused by high levels of androgens, oligomenorrhea, and polycystic ovarian morphology are necessary for diagnosis. This study aims to find a relationship between the genetic polymorphism of HNF1A and the risk of Polycystic Ovary Syndrome in a Sample of Iraqi Women. The study includes one hundred subjects of Iraqi women in Baghdad (15-35 years); patients were divided into three groups. The first group included Patients treated with metformin, the second group included Patients without metformin, and the third group included healthy. DNA was extracted, then the Genotyping polymorphism (rs1169288) of the HNF1A gene was done by RT-PCR. The AA genotype showed a higher frequency in control (p=0.001), while the CC genotype showed a higher frequency in the patients (p= 0.0001). Keywords: Polycystic ovary syndrome (PCOS), genetic polymorphism, HNF1A protein, Glucose and lipid profile.
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