{"title":"HNF1A基因多态性对伊拉克妇女多囊卵巢综合征风险的影响","authors":"Elham Ahmed Toama, Hamssa Ahmed Jasim","doi":"10.21931/rb/css/2023.08.02.10","DOIUrl":null,"url":null,"abstract":"Polycystic ovary syndrome (PCOS) is one of the most common causes of female\ninfertility. Clinical features caused by high levels of androgens, oligomenorrhea,\nand polycystic ovarian morphology are necessary for diagnosis. This study aims\nto find a relationship between the genetic polymorphism of HNF1A and the risk\nof Polycystic Ovary Syndrome in a Sample of Iraqi Women. The study includes\none hundred subjects of Iraqi women in Baghdad (15-35 years); patients were divided into three groups. The first group included Patients treated with metformin,\nthe second group included Patients without metformin, and the third group included healthy. DNA was extracted, then the Genotyping polymorphism\n(rs1169288) of the HNF1A gene was done by RT-PCR. The AA genotype\nshowed a higher frequency in control (p=0.001), while the CC genotype showed\na higher frequency in the patients (p= 0.0001).\nKeywords: Polycystic ovary syndrome (PCOS), genetic polymorphism, HNF1A\nprotein, Glucose and lipid profile.","PeriodicalId":201642,"journal":{"name":"Sumer 2","volume":"5 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Effect of HNF1A Gene Polymorphism on the Risk of Polycystic Ovary\\nSyndrome in a Sample of Iraqi Women\",\"authors\":\"Elham Ahmed Toama, Hamssa Ahmed Jasim\",\"doi\":\"10.21931/rb/css/2023.08.02.10\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Polycystic ovary syndrome (PCOS) is one of the most common causes of female\\ninfertility. Clinical features caused by high levels of androgens, oligomenorrhea,\\nand polycystic ovarian morphology are necessary for diagnosis. This study aims\\nto find a relationship between the genetic polymorphism of HNF1A and the risk\\nof Polycystic Ovary Syndrome in a Sample of Iraqi Women. The study includes\\none hundred subjects of Iraqi women in Baghdad (15-35 years); patients were divided into three groups. The first group included Patients treated with metformin,\\nthe second group included Patients without metformin, and the third group included healthy. DNA was extracted, then the Genotyping polymorphism\\n(rs1169288) of the HNF1A gene was done by RT-PCR. The AA genotype\\nshowed a higher frequency in control (p=0.001), while the CC genotype showed\\na higher frequency in the patients (p= 0.0001).\\nKeywords: Polycystic ovary syndrome (PCOS), genetic polymorphism, HNF1A\\nprotein, Glucose and lipid profile.\",\"PeriodicalId\":201642,\"journal\":{\"name\":\"Sumer 2\",\"volume\":\"5 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sumer 2\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21931/rb/css/2023.08.02.10\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sumer 2","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21931/rb/css/2023.08.02.10","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Effect of HNF1A Gene Polymorphism on the Risk of Polycystic Ovary
Syndrome in a Sample of Iraqi Women
Polycystic ovary syndrome (PCOS) is one of the most common causes of female
infertility. Clinical features caused by high levels of androgens, oligomenorrhea,
and polycystic ovarian morphology are necessary for diagnosis. This study aims
to find a relationship between the genetic polymorphism of HNF1A and the risk
of Polycystic Ovary Syndrome in a Sample of Iraqi Women. The study includes
one hundred subjects of Iraqi women in Baghdad (15-35 years); patients were divided into three groups. The first group included Patients treated with metformin,
the second group included Patients without metformin, and the third group included healthy. DNA was extracted, then the Genotyping polymorphism
(rs1169288) of the HNF1A gene was done by RT-PCR. The AA genotype
showed a higher frequency in control (p=0.001), while the CC genotype showed
a higher frequency in the patients (p= 0.0001).
Keywords: Polycystic ovary syndrome (PCOS), genetic polymorphism, HNF1A
protein, Glucose and lipid profile.