M. Díaz-Pérez , M.A. Hernández-Manzanares , V. Montes-Martínez , E.A. Sánchez-Valdivieso
{"title":"血清-谷氨酰胺转移酶，前列腺特异性抗原佐剂在前列腺癌诊断中的作用","authors":"M. Díaz-Pérez , M.A. Hernández-Manzanares , V. Montes-Martínez , E.A. Sánchez-Valdivieso","doi":"10.1016/j.uromx.2015.08.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>The aim of this study was to determine the relation of prostate-specific antigen to histopathologic and biochemical indicators in patients with a clinical prostate cancer diagnosis.</p></div><div><h3>Material and methods</h3><p>A cross-sectional study was conducted on patients 50 years and older that had a clinical diagnosis of prostate cancer within the time frame of March 2012 and August 2014. Prostate-specific antigen levels and histopathologic and biochemical data were analyzed through descriptive statistics, the Spearman correlation, ROC curves, and contingency tables.</p></div><div><h3>Results</h3><p>The median age of the patients was 71 years and the median prostate-specific antigen value was 8.1<!--> <!-->ng/ml (2<!--> <!-->ng/ml to 3,685<!--> <!-->ng/ml). Pathologic study confirmed prostate cancer diagnosis in 50 patients. There was an association between prostate-specific antigen levels and Gleason score (p<!--> <!--><<!--> <!-->0.05), as well as between prostate-specific antigen and gamma-glutamyl transferase (p<!--> <!--><<!--> <!-->0.05).</p></div><div><h3>Conclusions</h3><p>Gamma-glutamyl transferase determination is suggested for increasing prostate-specific antigen sensitivity and specificity. The number of patients was a limitation of our study.</p></div>","PeriodicalId":34909,"journal":{"name":"Revista mexicana de urologia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.uromx.2015.08.004","citationCount":"1","resultStr":"{\"title\":\"Gama-glutamil trasferasa en suero, adyuvante del antígeno prostático específico en el diagnóstico del cáncer de próstata\",\"authors\":\"M. Díaz-Pérez , M.A. Hernández-Manzanares , V. Montes-Martínez , E.A. Sánchez-Valdivieso\",\"doi\":\"10.1016/j.uromx.2015.08.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>The aim of this study was to determine the relation of prostate-specific antigen to histopathologic and biochemical indicators in patients with a clinical prostate cancer diagnosis.</p></div><div><h3>Material and methods</h3><p>A cross-sectional study was conducted on patients 50 years and older that had a clinical diagnosis of prostate cancer within the time frame of March 2012 and August 2014. Prostate-specific antigen levels and histopathologic and biochemical data were analyzed through descriptive statistics, the Spearman correlation, ROC curves, and contingency tables.</p></div><div><h3>Results</h3><p>The median age of the patients was 71 years and the median prostate-specific antigen value was 8.1<!--> <!-->ng/ml (2<!--> <!-->ng/ml to 3,685<!--> <!-->ng/ml). Pathologic study confirmed prostate cancer diagnosis in 50 patients. There was an association between prostate-specific antigen levels and Gleason score (p<!--> <!--><<!--> <!-->0.05), as well as between prostate-specific antigen and gamma-glutamyl transferase (p<!--> <!--><<!--> <!-->0.05).</p></div><div><h3>Conclusions</h3><p>Gamma-glutamyl transferase determination is suggested for increasing prostate-specific antigen sensitivity and specificity. The number of patients was a limitation of our study.</p></div>\",\"PeriodicalId\":34909,\"journal\":{\"name\":\"Revista mexicana de urologia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.uromx.2015.08.004\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista mexicana de urologia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S200740851500107X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista mexicana de urologia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S200740851500107X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Gama-glutamil trasferasa en suero, adyuvante del antígeno prostático específico en el diagnóstico del cáncer de próstata
Objective
The aim of this study was to determine the relation of prostate-specific antigen to histopathologic and biochemical indicators in patients with a clinical prostate cancer diagnosis.
Material and methods
A cross-sectional study was conducted on patients 50 years and older that had a clinical diagnosis of prostate cancer within the time frame of March 2012 and August 2014. Prostate-specific antigen levels and histopathologic and biochemical data were analyzed through descriptive statistics, the Spearman correlation, ROC curves, and contingency tables.
Results
The median age of the patients was 71 years and the median prostate-specific antigen value was 8.1 ng/ml (2 ng/ml to 3,685 ng/ml). Pathologic study confirmed prostate cancer diagnosis in 50 patients. There was an association between prostate-specific antigen levels and Gleason score (p < 0.05), as well as between prostate-specific antigen and gamma-glutamyl transferase (p < 0.05).
Conclusions
Gamma-glutamyl transferase determination is suggested for increasing prostate-specific antigen sensitivity and specificity. The number of patients was a limitation of our study.
期刊介绍：
Revista Mexicana de Urología (RMU) [Mexican Journal of Urology] (ISSN: 0185-4542 / ISSN electronic: 2007-4085) is bimonthly publication that disseminates research by academicians and professionals of the international medical community interested in urological subjects, in the format of original articles, clinical cases, review articles brief communications and letters to the editor. Owing to its nature, it is publication with international scope that disseminates contributions in Spanish and English that are rigorously reviewed by peers under the double blind modality. Neither journalistic documents nor those that lack rigorous medical or scientific support are suitable for publication.
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