应用胎盘冷冻提取物调节美洛昔康诱导的胃肠道和胃运动活动的变化

F. Hladkykh, M. Chyzh
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引用次数: 14

摘要

介绍。目前减少非甾体类抗炎药致溃疡性的方法主要是为了消除对胃粘膜的破坏作用,根据文献,质子泵抑制剂的使用甚至会加重肠病的病程。目标。探讨低温保存胎盘提取物对实验性美洛昔康诱导的胃病和肠病大鼠胃分泌状态和运动排泄活性的影响。方法。在非线性大鼠和小鼠上进行了一系列随机安慰剂对照研究,使用小肠诱导的胃肠道病变模型。采用标准方法研究大鼠胃分泌、小鼠胃排空功能和肠道运动功能。结果。服用美洛昔康后胃液量增加31.6±7.3% (p <0.05),总酸度增加7.7 (p=0.002);16.6]%,与完整动物相比,蠕动活动增加了18.9% (p<0.05)。冷冻胎盘提取物使游离酸度与总酸度之比降低了2.3倍(p=0.002),使其蠕动活性较完整动物降低了14.5% (p<0.05),具有统计学意义。美洛昔康与胎盘冻存液联合用药可使游离酸度与总酸度之比降低43.0±3.0%。结论。胎盘冷冻提取液与美洛昔康联合应用可消除美洛昔康引起的胃液分泌过多和胃运动亢进。冷冻提取物也被证明通过减少胃液的游离酸度和增加联合酸度来降低胃液的侵蚀性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MODULATION OF MELOXICAM-INDUCED CHANGES IN GASTROINTESTINAL AND MOTOR ACTIVITY OF THE STOMACH BY APPLYING PLACENTA CRYOEXTRACT
Introduction. Current approaches to reducing the ulcerogenicity of nonsteroidal anti-inflammatory drugs are aimed primarily at eliminating the damaging effect on the gastric mucosa, and according to the literature, the use of proton pump inhibitors can even worsen the course of enteropathy. Objectives. To characterize the influence of cryopreserved placenta extract on the state of secretory and motor-evacuation activity of the stomach under the conditions of experimental meloxicam-induced gastropathy and enteropathy. Methods. Serial randomized placebo-controlled studies were performed on nonlinear rats and mice using a model of small intestine-induced gastrointestinal lesions. Gastric secretion in rats, gastric evacuation function and intestinal motor function in mice were studied with the help of standard methods. Results. The administration of meloxicam leads to a statistically significant increase (p <0.05) in the volume of gastric secretion by 31.6±7.3%, an increase in total acidity (p=0.002) by 7.7 [7.7; 16.6]% and a statistically significant increase (p<0.05) in peristaltic activity by 18.9% relative to intact animals. The administration of cryopreserved placenta extract led to a statistically significant (p=0.002) decrease in the ratio of free and total acidity by 2.3 times, with a statistically significant decrease (p<0.05) by 14.5% in peristaltic activity relative to intact animals. The combined threaded administration of meloxicam and cryopreserved placenta extract was accompanied by a decrease in the ratio of free and total acidity by 43.0±3.0%. Conclusion. The combined application of placental cryoextract and meloxicam eliminates meloxicam-induced hypersecretion of gastric juice and gastric hypermobility. The cryoextract has also proved to reduce the aggressiveness of gastric juice by reducing its free and increasing combined acidity.
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