Genetic Profiling of the Nitric Oxide Synthases’ System in a 55-Year-Old Woman with the Tension-Type Headache and Arterial Hypertension Phenotype: Case Report

The tension-type headache (TTH) and arterial hypertension (AH) phenotype is a common overlap syndrome in adult patients. A genetically determined disturbance of the nitric oxide (NO) synthesis system is actively considered as one of the important possible pathogenetic mechanisms for the development of this phenotype. Neuronal NO-synthase is expressed both in the brain, skeletal muscles, and in the vascular endothelium; therefore, single-nucleotide variants of the NOS1 gene, encoding this enzyme, are the most interesting, but insufficiently studied genetic biomarkers of the TTH and AH phenotype. The aim of the case report is to present the experience of using genetic profiling of the nitric oxide synthases’ system in a 55-year-old patient with treatment-resistant TTH and AH phenotype.