海草代谢组学:基于海洋的药物发现的新见解

D. Jeyapragash, A. Saravanakumar, M. Yosuva
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引用次数: 2

摘要

代谢组学是“组学”方法的新领域之一,也是系统生物学中最年轻的三个领域之一,它为代谢网络如何被控制提供了广阔的前景,并与基因组学、转录组学和蛋白质组学等成熟的技术一起成为功能基因组学的补充工具。虽然代谢物谱分析已经开展了几十年,但由于一种分子调控的决定性机制,一些代谢物在人类生活中的重要性及其作为诊断标志物的用途现在才被认识到。因此,植物代谢组学旨在突出植物组织代谢产物库的特征,以响应其环境。海草,一种海洋亲水被子植物,经过三到四次从陆地植物进化回海洋。由于趋同进化,海草具有许多类似的获得性代谢适应,但它们的次级代谢在可被认为是真正的海草的四个科之间存在差异。从化学分类学的角度来看,海草中经常研究许多专门的代谢物。因此,本章将重点介绍海草的代谢组学,以探索其生物活性特性,以及利用组学方法研究海草非靶向代谢组学的分析技术平台的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seagrass Metabolomics: A New Insight towards Marine Based Drug Discovery
Metabolomics is one of the new field of “Omics” approach and the youngest triad of system biology, which provides a broad prospective of how metabolic networks are controlled and indeed emerged as a complementary tool to functional genomics with well-established technologies for genomics, transcriptomics and proteomics. Though, metabolite profiling has been carried out for decades, owing to decisive mechanism of a molecule regulation, the importance of some metabolites in human regimen and their use as diagnostic markers is now being recognized. Plant metabolomics therefore aims to highlight the characterization of metabolite pool of a plant tissue in response to its environment. Seagrassses, a paraphyletic group of marine hydrophilous angiosperms which evolved three to four times from land plants back to the sea. Seagrasses share a number of analogous acquired metabolic adaptations owing to their convergent evolution, but their secondary metabolism varied among the four families that can be considered as true seagrasses. From a chemotaxonomic point of view, numerous specialized metabolites have often been studied in seagrasses. Hence, this chapter focus the metabolome of seagrasses in order to explore their bioactive properties and the recent advancements adopted in analytical technology platforms to study the non-targeted metabolomics of seagrasses using OMICS approach.
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