G E Rice, S P Brennecke, K F Scott, G M Smith, I A Rajkovic, G J Bishop
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引用次数: 0
摘要
测定了110名妊娠期妇女外周血免疫反应性磷脂酶A2 (irPLA2) (II型，非胰腺)的浓度。irPLA2的浓度在怀孕期间没有显著变化(5.7 +/- 0.6 ng/ml, n = 72)，直到分娩开始。与非分娩妇女相比，irPLA2浓度显著升高与早产(13.3 +/- 2.4 ng/ml, n = 15, p小于0.02)和足月分娩(10.4 +/- 1.7 ng/ml, n = 23, p小于0.02)相关。这些数据表明，母体血浆irPLA2可能反映了分娩相关的人类妊娠组织类二十烷形成增加的机制。
Elevated maternal plasma immunoreactive phospholipase A2 in human preterm and term labour.
Peripheral plasma concentrations of immunoreactive phospholipase A2 (irPLA2) (Type II, non-pancreatic) were determined in 110 women during pregnancy. The concentration of irPLA2 did not significantly change during pregnancy (5.7 +/- 0.6 ng/ml, n = 72) until the onset of labour. When compared with non-labouring women, irPLA2 concentrations were significantly elevated in association with both preterm labour (13.3 +/- 2.4 ng/ml, n = 15, p less than 0.02) and labour at term (10.4 +/- 1.7, n = 23, p less than 0.02). These data suggest that maternal plasma irPLA2 may be reflective of the mechanism(s) underlying the labour-associated increase in human gestational tissue eicosanoid formation.
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