[75Se]亚硒酸盐和[75Se]硒酸盐在小鼠肝癌发展过程中的波动

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology Pub Date : 1992-07-01 DOI:10.1016/0883-2897(92)90151-N

Muhammad Ashraf Tariq , Ivor L. Preiss

{"title":"[75Se]亚硒酸盐和[75Se]硒酸盐在小鼠肝癌发展过程中的波动","authors":"Muhammad Ashraf Tariq , Ivor L. Preiss","doi":"10.1016/0883-2897(92)90151-N","DOIUrl":null,"url":null,"abstract":"<div><p>The distribution of selenate and selenite selenium in C57L/J mice during the progression of BW7756 murine hepatoma was investigated using intra-ocular injection with the oxyanions labeled with <sup>75</sup>Se radioisotope. Comparison is made with the normal distribution of selenium studied by the RIXRF method. The trace elemental profiles, TEP, for the two oxidation states are compared in healthy and disease states. It has been found that the presence of tumor significantly changes the level of tracer in various uninvolved organs. These changes are prominent in the early growth phase of the tumor. The two oxidation states show differences in the TEP for kidney, spleen, stomach and testes.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 5","pages":"Pages 555-561"},"PeriodicalIF":0.0000,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90151-N","citationCount":"4","resultStr":"{\"title\":\"[75Se]selenite and [75Se]selenate fluctuations during the development of murine hepatoma\",\"authors\":\"Muhammad Ashraf Tariq , Ivor L. Preiss\",\"doi\":\"10.1016/0883-2897(92)90151-N\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The distribution of selenate and selenite selenium in C57L/J mice during the progression of BW7756 murine hepatoma was investigated using intra-ocular injection with the oxyanions labeled with <sup>75</sup>Se radioisotope. Comparison is made with the normal distribution of selenium studied by the RIXRF method. The trace elemental profiles, TEP, for the two oxidation states are compared in healthy and disease states. It has been found that the presence of tumor significantly changes the level of tracer in various uninvolved organs. These changes are prominent in the early growth phase of the tumor. The two oxidation states show differences in the TEP for kidney, spleen, stomach and testes.</p></div>\",\"PeriodicalId\":14328,\"journal\":{\"name\":\"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology\",\"volume\":\"19 5\",\"pages\":\"Pages 555-561\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0883-2897(92)90151-N\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/088328979290151N\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/088328979290151N","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 4

摘要

采用75Se放射性同位素标记氧阴离子眼内注射的方法，研究了BW7756小鼠肝癌进展过程中硒酸盐和亚硒酸盐硒在C57L/J小鼠体内的分布。并与RIXRF法测定的硒的正态分布进行了比较。在健康和疾病状态下，比较了两种氧化状态的微量元素谱，TEP。研究发现，肿瘤的存在显著改变了各种未受累器官的示踪剂水平。这些变化在肿瘤的早期生长阶段非常明显。两种氧化状态对肾、脾、胃和睾丸的TEP有不同的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

[75Se]selenite and [75Se]selenate fluctuations during the development of murine hepatoma

The distribution of selenate and selenite selenium in C57L/J mice during the progression of BW7756 murine hepatoma was investigated using intra-ocular injection with the oxyanions labeled with ⁷⁵Se radioisotope. Comparison is made with the normal distribution of selenium studied by the RIXRF method. The trace elemental profiles, TEP, for the two oxidation states are compared in healthy and disease states. It has been found that the presence of tumor significantly changes the level of tracer in various uninvolved organs. These changes are prominent in the early growth phase of the tumor. The two oxidation states show differences in the TEP for kidney, spleen, stomach and testes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

自引率

0.00%

发文量