{"title":"75Se-和131i标记单克隆抗体在裸鼠体内生物分布的比较","authors":"Jakobína Grétarsdóttir , Eva Forssell Aronsson , Lars Jacobsson , Ólöf Hafsteinsdóttir , Stig Holmberg , Larsolof Hafström , Sture Lindegren , Börje Karlsson , Leif Lindholm , Sören Mattsson","doi":"10.1016/0883-2897(92)90131-H","DOIUrl":null,"url":null,"abstract":"<div><p>A monoclonal antibody, C-215, against colon cancer, was internally labelled with [<sup>75</sup>Se]methionine. The biodistribution was studied in tumour-bearing nude mice and compared with the biodistribution of [<sup>131</sup>I]C-215. The tissue uptake was divided into three parts: antibody bound to the antigen, antibody in the extracellular space and uptake of the released radionuclide. [<sup>75</sup>Se]C-215 showed a greater amount of antigen-bound antibody in the tumour, but also a greater unspecific uptake both in tumour and normal tissue.</p></div>","PeriodicalId":14328,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","volume":"19 7","pages":"Pages 719-726"},"PeriodicalIF":0.0000,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2897(92)90131-H","citationCount":"2","resultStr":"{\"title\":\"Comparison of the biodistribution of 75Se- and 131I-labelled monoclonal antibodies in nude mice\",\"authors\":\"Jakobína Grétarsdóttir , Eva Forssell Aronsson , Lars Jacobsson , Ólöf Hafsteinsdóttir , Stig Holmberg , Larsolof Hafström , Sture Lindegren , Börje Karlsson , Leif Lindholm , Sören Mattsson\",\"doi\":\"10.1016/0883-2897(92)90131-H\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A monoclonal antibody, C-215, against colon cancer, was internally labelled with [<sup>75</sup>Se]methionine. The biodistribution was studied in tumour-bearing nude mice and compared with the biodistribution of [<sup>131</sup>I]C-215. The tissue uptake was divided into three parts: antibody bound to the antigen, antibody in the extracellular space and uptake of the released radionuclide. [<sup>75</sup>Se]C-215 showed a greater amount of antigen-bound antibody in the tumour, but also a greater unspecific uptake both in tumour and normal tissue.</p></div>\",\"PeriodicalId\":14328,\"journal\":{\"name\":\"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology\",\"volume\":\"19 7\",\"pages\":\"Pages 719-726\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0883-2897(92)90131-H\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/088328979290131H\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/088328979290131H","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparison of the biodistribution of 75Se- and 131I-labelled monoclonal antibodies in nude mice
A monoclonal antibody, C-215, against colon cancer, was internally labelled with [75Se]methionine. The biodistribution was studied in tumour-bearing nude mice and compared with the biodistribution of [131I]C-215. The tissue uptake was divided into three parts: antibody bound to the antigen, antibody in the extracellular space and uptake of the released radionuclide. [75Se]C-215 showed a greater amount of antigen-bound antibody in the tumour, but also a greater unspecific uptake both in tumour and normal tissue.
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