{"title":"5-HT1A受体与涡虫腺苷酸环化酶正偶联的鉴定","authors":"P. Cretì , A. Capasso , M. Grasso , E. Parisi","doi":"10.1016/S0309-1651(06)80062-7","DOIUrl":null,"url":null,"abstract":"<div><p>The adenylate cyclase system present in particulate fractions prepared from two planarian species was tested for sensitivity to various neurotransmitters. While dopamine and other catecholamines were ineffective, serotonin was capable of stimulating the enzyme. Among the various serotonin agonists tested, only 8-OH-DPAT resulted effective on the adenylate cyclase activity, thus suggesting the presence in planarians of a serotonin receptor of the type 5-HT<sub>1A</sub>.</p></div>","PeriodicalId":75683,"journal":{"name":"Cell biology international reports","volume":"16 5","pages":"Pages 427-432"},"PeriodicalIF":0.0000,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0309-1651(06)80062-7","citationCount":"17","resultStr":"{\"title\":\"Identification of a 5-HT1A receptor positively coupled to planarian adenylate cyclase\",\"authors\":\"P. Cretì , A. Capasso , M. Grasso , E. Parisi\",\"doi\":\"10.1016/S0309-1651(06)80062-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The adenylate cyclase system present in particulate fractions prepared from two planarian species was tested for sensitivity to various neurotransmitters. While dopamine and other catecholamines were ineffective, serotonin was capable of stimulating the enzyme. Among the various serotonin agonists tested, only 8-OH-DPAT resulted effective on the adenylate cyclase activity, thus suggesting the presence in planarians of a serotonin receptor of the type 5-HT<sub>1A</sub>.</p></div>\",\"PeriodicalId\":75683,\"journal\":{\"name\":\"Cell biology international reports\",\"volume\":\"16 5\",\"pages\":\"Pages 427-432\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0309-1651(06)80062-7\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell biology international reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0309165106800627\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell biology international reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0309165106800627","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Identification of a 5-HT1A receptor positively coupled to planarian adenylate cyclase
The adenylate cyclase system present in particulate fractions prepared from two planarian species was tested for sensitivity to various neurotransmitters. While dopamine and other catecholamines were ineffective, serotonin was capable of stimulating the enzyme. Among the various serotonin agonists tested, only 8-OH-DPAT resulted effective on the adenylate cyclase activity, thus suggesting the presence in planarians of a serotonin receptor of the type 5-HT1A.
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