Nanoscale Lipidic Carrier Systems: Importance of Preparation Method and Solvents

Nanoscale lipidic carrier systems have crucial role in drug delivery, drug targeting, diagnostics and nanotherapy. These systems include liposome, nanoliposome, archaeosome, vesicular gels and more recently introduced tocosome. They can accommodate water-soluble material in their aqueous compartment(s) and, if required simultaneously, lipid-soluble substances in their lipid phases. There are already a number of approved liposomal and nanoliposomal products on the market for Human use. However, in order to improve the quality, shelf-life and safety of these products, it is necessary to pay particular attention to the choice of manufacturing method and especially selection of solvents and co-solvents. This entry will focus on the importance of preparation methods and solvents in the manufacture of lipidic nanocarriers.