环状核糖核酸的生物发生和解除管制及其在人类癌症中的作用

Rajakishore Mishra
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引用次数: 1

摘要

核糖核酸(RNA)在分子生物学的中心法则中占有中心地位。它们是带有核糖的核苷酸,呈线性或环状。线性RNA有不同的类型,包括核糖体RNA (rRNA)、信使RNA (mRNA)、转移RNA (t-RNA)、小核RNA (snRNA)和非常小/微RNA (microRNAs)。环状RNA (circRNA)是一组非编码RNA,稳定的分子,最近被发现并与不同基因,RNA包括microrna的调控有关。目前对这些分子的理解表明,这些环状rna是相当保守的,并表现出组织特异性的表达模式。这些分子与不同的致病条件有关,并与包括癌症在内的多种疾病有关。因此,环状rna有助于肿瘤的发生,这些分子显示出成为未来诊断、预后的预测性生物标志物的潜力,甚至可以作为个性化治疗的靶标。因此,这些生物分子将频繁暴露,其新的细胞作用将很快出现。这篇综述概述了circRNA在癌症研究中的当前趋势、局限性和未来潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bio-genesis and deregulation of circular ribonucleic acid and their role in human cancer
RiboNucleic Acid (RNA) occupies the center position in the central dogma of molecular biology. These are the nucleotide with a ribose sugar and are found either in linear or circular form. The linear RNAs are of different types and include ribosomal RNA (rRNA), messenger RNA (mRNA), transfer RNA (t-RNA), small nuclear (snRNA) RNA, and very small/micro RNA (microRNAs). The circular (circRNA) RNA is a group of noncoding RNA, stable molecules, established recently and linked with the regulation of different genes, RNAs including microRNAs. The current understanding of these molecules suggests that these circRNAs are fairly conserved and show tissue-specific expression patterns. These molecules are connected with different pathogenic conditions and associated with verities of diseases, including cancer. CircRNAs are thus contributing to tumorigenesis, and these molecules show the potential to become future predictive biomarkers for diagnosis, prognosis and even can be targeted in personalized therapy. Hence, these bio-molecules will get exposed frequently, and their new cellular role will emerge, soon. This review outlines the current trend, limitations, and future potential of circRNA in cancer research.
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