List of Figures and Maps

I Dendrogram tree of global population relationships with five Nilgiri tribes II Tribal dominated states of India III Tribal populations in six taluks of the Nilgiri district IVa Global distribution of the HBS data points IVb Global distribution of the sickle cell gene V Protein of Haemoglobin A, Haemoglobin S, Haemoglobin SS VI Structure of normal RBC and Sickled RBC VII Two parents with sickle cell disease VIII One parent with sickle cell disease and sickle cell trait IX One parent with sickle cell disease and the other parent carries normal genes X Two Parents with sickle cell trait XI One parent with the sickle cell trait and the other as normal 2.1 Flowline description of the approach towards the present research 3.1 Location of study area 3.2 The distribution of six primitive tribal groups in the Nilgiri district of Tamil Nadu 5.1 Flowchart of the methodology adopted for the study 5.2 Link between the sections I – V of the study 6.1.1 Distribution of sickle cell disease cases in the Nilgiri district of Tamil Nadu 6.1.2 Distribution of sickle cell disease among total male in the Nilgiri district of Tamil Nadu 6.1.3 Distribution of sickle cell disease among total female in the Nilgiri district of Tamil Nadu 6.1.4 Distribution of SCD among four tribes of different age group 6.1.5 Age specific incidence rate of Sickle cell disease for different age category (A) Total cases, (B) Male cases and (C) Females cases 6.1.6 Taluk wise age specific rates for sickle cell disease in the Nilgiri district of Tamil Nadu 6.1.7 Taluk wise age adjusted rates for sickle cell disease for the Nilgiri district of Tamil Nadu 6.1.8 Distribution of SS and AS incidence of sickle cell disease for male and female in the Nilgiri district of Tamil Nadu