{"title":"fc受体在毛细胞白血病细胞上的强表达","authors":"E.P. Rieber , J.G. Saal , G. Riethmüller , H.W.v. Heyden , H.D. Waller","doi":"10.1016/S0300-872X(76)80043-1","DOIUrl":null,"url":null,"abstract":"<div><p>The neoplastic cells of a patient with hairy cell leukemia were found to express a high Fe-receptor activity on their surface. When the Fc-receptors were determined quantitatively by measuring the uptake of <sup>125</sup>I-labelled aggregated IgG under saturation conditions, it was found that the hairy cells bound approximately 3 times more aggregated IgG than normal adherent mononuclear cells. The bound <sup>125</sup>I-Agg. IgG was evenly distributed on the cell surface when the cells were labelled at 4°C and was rapidly redistributed in form of a cap at one cell pole during incubation at 20°C.</p></div>","PeriodicalId":101289,"journal":{"name":"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie","volume":"151 3","pages":"Pages 282-288"},"PeriodicalIF":0.0000,"publicationDate":"1976-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0300-872X(76)80043-1","citationCount":"12","resultStr":"{\"title\":\"Strong Expression of Fc-Receptors on Leukemic Cells in Hairy Cell Leukemia\",\"authors\":\"E.P. Rieber , J.G. Saal , G. Riethmüller , H.W.v. Heyden , H.D. Waller\",\"doi\":\"10.1016/S0300-872X(76)80043-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The neoplastic cells of a patient with hairy cell leukemia were found to express a high Fe-receptor activity on their surface. When the Fc-receptors were determined quantitatively by measuring the uptake of <sup>125</sup>I-labelled aggregated IgG under saturation conditions, it was found that the hairy cells bound approximately 3 times more aggregated IgG than normal adherent mononuclear cells. The bound <sup>125</sup>I-Agg. IgG was evenly distributed on the cell surface when the cells were labelled at 4°C and was rapidly redistributed in form of a cap at one cell pole during incubation at 20°C.</p></div>\",\"PeriodicalId\":101289,\"journal\":{\"name\":\"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie\",\"volume\":\"151 3\",\"pages\":\"Pages 282-288\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1976-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0300-872X(76)80043-1\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0300872X76800431\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0300872X76800431","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Strong Expression of Fc-Receptors on Leukemic Cells in Hairy Cell Leukemia
The neoplastic cells of a patient with hairy cell leukemia were found to express a high Fe-receptor activity on their surface. When the Fc-receptors were determined quantitatively by measuring the uptake of 125I-labelled aggregated IgG under saturation conditions, it was found that the hairy cells bound approximately 3 times more aggregated IgG than normal adherent mononuclear cells. The bound 125I-Agg. IgG was evenly distributed on the cell surface when the cells were labelled at 4°C and was rapidly redistributed in form of a cap at one cell pole during incubation at 20°C.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
