O. Nuchuchua, W. Sajomsang, Pattarapond Gonil, Nuttaporn Pimphd, S. Chaleawlert-umpon, I. Sramala, Somsak Saesoo, A. Soottitantawat, U. Ruktanonchai
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引用次数: 0
摘要
本研究的目的是合成两种水溶性β - cd接枝壳聚糖衍生物并测定其生物活性;带间隔剂的β cd -壳聚糖(QCDCA22-g-CS)和不带间隔剂的β cd -壳聚糖(QCD23-g-CS)作为一种新型的粘膜递送生物材料。根据粘蛋白颗粒法，QCD23-g-CS对粘蛋白具有较强的黏附性。虽然QCDCA22-g-CS和QCD23-g-CS在24小时对白色念珠菌均表现出较高的抑菌活性，但QCD23-g-CS的抑菌活性明显高于QCDCA22-g-CS。
Synthesis and characterization of ²-cyclodextrin-grafted chitosan derivatives on its mucoadhesion and antibacterial activities
The aims of this study were to synthesize and determine the biological activities of two types of water-soluble βCD-grafted chitosan derivatives; βCD-grafted chitosan with spacer (QCDCA22-g-CS) and βCD-grafted chitosan without spacer (QCD23-g-CS) as a novel biomaterial for mucosal delivery. Difference in their chemical structure were defined by 1H-NMR According to mucin particle method, QCD23-g-CS showed stronger mucoadhesion towards mucin. Although both QCDCA22-g-CS and QCD23-g-CS demonstrated high antibacterial activity towards Candida albicans at 24 hours, QCD23-g-CS demonstrated much higher activity than QCDCA22-g-CS.
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