Caio Felipe de Araujo Ribas Cheohen, Bruce Veiga Andriolo, Manuela Leal da Silva
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引用次数: 1
摘要
活性药物成分(api)是可用于制造药物的分子。巴西卫生监管机构(Agência Nacional de vigilatalncia Sanitária)负责监督和批准巴西境内所有药品的生产和销售。四个不同的数据库，包括346个原料药中的336个，是根据巴西药典第6版第2卷“活性药物成分”专论中的原料药文本信息创建的。每个数据库都由不同的扩展文件组成，它们是:二维sdf、三维sdf、mol2和PDBQT文件扩展名，通过使用OpenBabel和Marvin Sketch软件进行转换。
Database of Active Pharmaceutical Ingredients (APIs) present in the Brazilian Pharmacopeia
Active Pharmaceutical Ingredients (APIs) are molecules that can be used for the manufacturing of Drugs. The Brazilian Health Regulatory Agency (Agência Nacional de Vigilância Sanitária) is responsible for the oversight and approval of production and distribution of all drugs in Brazilian territory. Four different databases, including 336 out of the 346 total APIs, were created from the APIs text information available in the 6th edition of the Brazilian pharmacopeia, volume 2, “Active Pharmaceutical Ingredients” monography. Each database is composed by a different extension file, they are: two-dimensional sdf, three-dimensional sdf, mol2 and PDBQT file extensions, converted by using OpenBabel and Marvin Sketch software.
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