THE MECHANISM OF ACTION OF THE GEL FORM OF COLLAGEN IN DIABETIC WOUNDS

The work is devoted to a review of the options for the use of collagen and materials based on collagen in medicine and the pharmaceutical industry. Tissue engineering is a medical science dealing with the reproduction of biological tissues and organs. This area of medicine opens avenues for the creation of organs and tissues using biomaterials and nanostructures to sustain their development, maintenance, and function repair in a living organism. Among the many types of cells that can have a clinical effect, of particular interest are dermal fibroblasts, which are a heterogeneous population of mesenchymal cells and play a key role in the regulation of cell interactions and maintaining skin homeostasis. Currently, there are more than 60 modern cellular or tissue drugs for the treatment of wounds, which makes it difficult to choose an appropriate, safe, and effective adjuvant therapy. Recent years have witnessed a major leap in 3D technology for the reproduction of biological structures. Increasing attention is being paid to the controlled design and production of 2D–3D structures consisting of biological materials and viable cells, the procedure defined as bioproduction or bio-prototyping. Skin substitutes obtained with the bio-prototyping technology possess a wide range of medical applications, primarily to compensate for resident skin deficiency in wound healing.