{"title":"123i标记mIBG的常规生产及质量控制","authors":"D. Du T. Rossouw","doi":"10.1016/0883-2889(92)90211-V","DOIUrl":null,"url":null,"abstract":"<div><p>An existing method, developed in our laboratory, has been further improved for the large scale routine production of [<sup>123</sup>I]mIBG. Losses of <sup>123</sup>I during production have been decreased from 16% to <3% and labelling efficiencies of >98% are now consistently obtained. A sensitive HPLC quality control method for [<sup>123</sup>I]mIBG, based on reverse-phase ion-pair chromatography, has also been developed.</p></div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 10","pages":"Pages 1301-1302"},"PeriodicalIF":0.0000,"publicationDate":"1992-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90211-V","citationCount":"8","resultStr":"{\"title\":\"Routine production and quality control of 123I-labelled mIBG at NAC\",\"authors\":\"D. Du T. Rossouw\",\"doi\":\"10.1016/0883-2889(92)90211-V\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>An existing method, developed in our laboratory, has been further improved for the large scale routine production of [<sup>123</sup>I]mIBG. Losses of <sup>123</sup>I during production have been decreased from 16% to <3% and labelling efficiencies of >98% are now consistently obtained. A sensitive HPLC quality control method for [<sup>123</sup>I]mIBG, based on reverse-phase ion-pair chromatography, has also been developed.</p></div>\",\"PeriodicalId\":14288,\"journal\":{\"name\":\"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes\",\"volume\":\"43 10\",\"pages\":\"Pages 1301-1302\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0883-2889(92)90211-V\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/088328899290211V\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/088328899290211V","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Routine production and quality control of 123I-labelled mIBG at NAC
An existing method, developed in our laboratory, has been further improved for the large scale routine production of [123I]mIBG. Losses of 123I during production have been decreased from 16% to <3% and labelling efficiencies of >98% are now consistently obtained. A sensitive HPLC quality control method for [123I]mIBG, based on reverse-phase ion-pair chromatography, has also been developed.
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