{"title":"人肝细胞生长因子刺激hh -6克隆5人肝母细胞瘤细胞的生长","authors":"Masahiro Miyazaki , Eiichi Gohda , So Tsuboi , Hirohito Tsubouchi , Yasushi Daikuhara , Masayoshi Namba , Itaru Yamamoto","doi":"10.1016/S0309-1651(06)80108-6","DOIUrl":null,"url":null,"abstract":"<div><p>The effects of human hepatocyte growth factor (hHGF), a potent mitogen for rat and human hepatocytes in primary culture, on proliferation of human hepatoma and hepatoblastoma cells were examined. Out of five cell lines; HLE, HuH-6 Clone 5, HuH-7, PLC/PRF/5, and Hep G2, only HuH-6 Clone 5 cells were stimulated by recombinant hHGF. Both native and recombinant hHGFs caused dose-dependent increases in cell number and DNA synthesis of cells. This stimulation was strongly inhibited by anti-hHGF monoclonal antibody.</p></div>","PeriodicalId":75683,"journal":{"name":"Cell biology international reports","volume":"16 2","pages":"Pages 145-154"},"PeriodicalIF":0.0000,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0309-1651(06)80108-6","citationCount":"35","resultStr":"{\"title\":\"Human hepatocyte growth factor stimulates the growth of HuH-6 clone 5 human hepatoblastoma cells\",\"authors\":\"Masahiro Miyazaki , Eiichi Gohda , So Tsuboi , Hirohito Tsubouchi , Yasushi Daikuhara , Masayoshi Namba , Itaru Yamamoto\",\"doi\":\"10.1016/S0309-1651(06)80108-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effects of human hepatocyte growth factor (hHGF), a potent mitogen for rat and human hepatocytes in primary culture, on proliferation of human hepatoma and hepatoblastoma cells were examined. Out of five cell lines; HLE, HuH-6 Clone 5, HuH-7, PLC/PRF/5, and Hep G2, only HuH-6 Clone 5 cells were stimulated by recombinant hHGF. Both native and recombinant hHGFs caused dose-dependent increases in cell number and DNA synthesis of cells. This stimulation was strongly inhibited by anti-hHGF monoclonal antibody.</p></div>\",\"PeriodicalId\":75683,\"journal\":{\"name\":\"Cell biology international reports\",\"volume\":\"16 2\",\"pages\":\"Pages 145-154\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0309-1651(06)80108-6\",\"citationCount\":\"35\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell biology international reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0309165106801086\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell biology international reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0309165106801086","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Human hepatocyte growth factor stimulates the growth of HuH-6 clone 5 human hepatoblastoma cells
The effects of human hepatocyte growth factor (hHGF), a potent mitogen for rat and human hepatocytes in primary culture, on proliferation of human hepatoma and hepatoblastoma cells were examined. Out of five cell lines; HLE, HuH-6 Clone 5, HuH-7, PLC/PRF/5, and Hep G2, only HuH-6 Clone 5 cells were stimulated by recombinant hHGF. Both native and recombinant hHGFs caused dose-dependent increases in cell number and DNA synthesis of cells. This stimulation was strongly inhibited by anti-hHGF monoclonal antibody.
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