18三体羊膜细胞碱性磷酸酶和磷酸酪氨酸磷酸酶活性的研究。

Enzyme Pub Date : 1992-01-01 DOI:10.1159/000468805

H Vergnes, J Grozdea, A Brisson-Lougarre, G Bourrouillou, P Colombies

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引用次数: 0

摘要

在培养的爱德华综合征(18三体)胎儿羊膜细胞中，测定了碱性磷酸酶和磷酸酪氨酸磷酸酶两种蛋白磷酸酶的活性。与正常胎儿细胞相比，每种酶的行为都不同。碱性磷酸酶显著降低，而磷酸酪氨酸磷酸酶维持正常水平。讨论了这些酶测定在这种严重染色体缺陷的筛选过程中的作用。

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Alkaline phosphatase and phosphotyrosine phosphatase activities of cultured amniotic cells with trisomy 18.

In cultured amniotic cells from fetuses with Edward's syndrome (trisomy 18), the activities of two protein phosphatases, alkaline phosphatase and phosphotyrosine phosphatase, were measured. Comparison with normal fetal cells showed a different behavior for each enzyme. Alkaline phosphatase was significantly lowered while phosphotyrosine phosphatase remained at normal levels. The interest of these enzyme assays in the screening procedure of this severe chromosome defect is discussed.

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