韩国加湿器消毒剂对健康的不良影响:聚六亚甲基胍磷酸盐的肺毒性。

Ha-Ryong Kim, Gi-Wook Hwang, A. Naganuma, K. Chung
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引用次数: 42

摘要

2011年,接触加湿器消毒剂被确定为韩国爆发肺部疾病的潜在原因。据估计,自加湿器消毒剂投入商业使用以来,已有超过800万人接触过加湿器消毒剂——一种添加到加湿器水中以防止微生物生长的化学物质。涉及的加湿器消毒剂产品的主要成分是聚六亚甲基胍磷酸(PHMG-P),一种胍基抗菌剂。在患者肺部观察到的病变与暴露于PHMG-P的实验动物相似。在本文中,我们概述了PHMG-P的物理化学和毒理学特性,并介绍了其肺毒性的推测机制,主要基于迄今为止的研究成果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adverse health effects of humidifier disinfectants in Korea: lung toxicity of polyhexamethylene guanidine phosphate.
Exposure to humidifier disinfectants was identified in 2011 as the potential cause of an outbreak of lung disease in Korea. It is estimated that over 8 million people have been exposed to humidifier disinfectants-chemicals added to the water used in humidifiers to prevent the growth of microorganisms-since their commercial introduction. The primary component of humidifier disinfectant products involved was polyhexamethylene guanidine phosphate (PHMG-P), a guanidine-based antimicrobial agent. Lesions observed in the lungs of patients were similar to those observed in laboratory animals exposed to PHMG-P. In this review, we outline the physicochemical and toxicological properties of PHMG-P, and introduce a putative mechanism for its lung toxicity based in large part on research findings to date.
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