{"title":"代谢组学在系统毒理学:走向个性化医疗","authors":"L. Schnackenberg, Jinchun Sun, R. Beger","doi":"10.1002/9780470744307.GAT217","DOIUrl":null,"url":null,"abstract":"Metabolomics along with systems biology technologies such as transcriptomics and proteomics has the capability of providing translational diagnostic, prognostic and mechanistic biomarkers of drug-induced injury. Metabolomics has several advantages over the other omics platforms, such as ease of sample preparation, data acquisition and use of biofluids collected through minimally invasive procedures in pre-clinical and clinical studies. The role of metabolomics in systems toxicology is reviewed and examples of metabolomics in pre-clinical and clinical studies are provided. The role of metabolomics in personalized medicine is provided with special sections focusing on drug–drug and drug–nutrient interactions, metabolic fluxes and challenge tests. \n \n \nKeywords: \n \nmetabolomics; \nmetabonomics; \nmetabolic fluxes; \nbiomarkers; \npersonalized medicine; \nsystems biology","PeriodicalId":325382,"journal":{"name":"General, Applied and Systems Toxicology","volume":"61 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2011-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Metabolomics in Systems Toxicology: Towards Personalized Medicine\",\"authors\":\"L. Schnackenberg, Jinchun Sun, R. Beger\",\"doi\":\"10.1002/9780470744307.GAT217\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Metabolomics along with systems biology technologies such as transcriptomics and proteomics has the capability of providing translational diagnostic, prognostic and mechanistic biomarkers of drug-induced injury. Metabolomics has several advantages over the other omics platforms, such as ease of sample preparation, data acquisition and use of biofluids collected through minimally invasive procedures in pre-clinical and clinical studies. The role of metabolomics in systems toxicology is reviewed and examples of metabolomics in pre-clinical and clinical studies are provided. The role of metabolomics in personalized medicine is provided with special sections focusing on drug–drug and drug–nutrient interactions, metabolic fluxes and challenge tests. \\n \\n \\nKeywords: \\n \\nmetabolomics; \\nmetabonomics; \\nmetabolic fluxes; \\nbiomarkers; \\npersonalized medicine; \\nsystems biology\",\"PeriodicalId\":325382,\"journal\":{\"name\":\"General, Applied and Systems Toxicology\",\"volume\":\"61 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"General, Applied and Systems Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/9780470744307.GAT217\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"General, Applied and Systems Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/9780470744307.GAT217","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Metabolomics in Systems Toxicology: Towards Personalized Medicine
Metabolomics along with systems biology technologies such as transcriptomics and proteomics has the capability of providing translational diagnostic, prognostic and mechanistic biomarkers of drug-induced injury. Metabolomics has several advantages over the other omics platforms, such as ease of sample preparation, data acquisition and use of biofluids collected through minimally invasive procedures in pre-clinical and clinical studies. The role of metabolomics in systems toxicology is reviewed and examples of metabolomics in pre-clinical and clinical studies are provided. The role of metabolomics in personalized medicine is provided with special sections focusing on drug–drug and drug–nutrient interactions, metabolic fluxes and challenge tests.
Keywords:
metabolomics;
metabonomics;
metabolic fluxes;
biomarkers;
personalized medicine;
systems biology
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