E Deharo, M Sauvain, C Moretti, B Richard, E Ruiz, G Massiot
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[Antimalarial effect of n-hentriacontanol isolated from Cuatresia sp (Solanaceae)].
The antimalarial activity of the fatty alcohol, n-hentriacontanol, isolated from the bolivian Solanaceae, Cuatresia sp, is investigated in vivo through a classical four-day suppressive test against Plasmodium berghei and P. vinckei in mice. This product markedly reduced the virulence of experimentally induced P. vinckei infection. n-Hentriacontanol belongs to a new class of antimalarial natural compounds to be exploited for therapeutic purposes.
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