儿童围手术期凝血问题。

A M Mingers
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引用次数: 0

摘要

在儿童术前进行凝血诊断是为了证明或排除先天性凝血障碍或获得性血管性血友病。新生儿的凝血系统与成人的凝血系统以及单个参数达到成人值的时间有很大不同。将凝血筛查简化为测定aPTT和Quick试验,容易忽略严重的血液学疾病,如血管性血友病(von Willebrand disease),该疾病常见于儿童期,且常合并正常aPTT值。有时患有腺样体肥大的儿童aPTT暂时延长,而其他凝血参数可能由于狼疮抑制剂而正常。当凝血因子缺乏的儿童需要高剂量的凝血浓缩物时,可以通过提前一段时间测定恢复和半衰期来减少实验室对照的数量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Perioperative blood coagulation problems in children].

During childhood preoperative coagulation diagnosis is performed to prove or to rule out an inborn coagulation disorder or an acquired von Willebrand disease. The coagulation system of the newborn differs considerably from that of the adults as well as the time in which the single parameters reach adult values. Reducing the coagulation screening to the determination of aPTT and Quick test neglects severe hemostaseological disorders easily, such as von Willebrand disease which is often observed in childhood and often combined with normal aPTT values. Sometimes children affected with hypertrophy of the adenoids have temporary aPTT prolongations combined with normal values for the other coagulation parameters possibly due to lupus inhibitors. When children with deficiencies of coagulation factors need high doses of coagulation concentrates, the number of laboratory controls may be reduced by determination of recovery and the half-life period some time before.

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