{"title":"多烯脂肪酸在大鼠急性炎症发展中的作用。","authors":"O I Kirillov, N A Gubar', O V Petrukhin","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of n6 and n3 polyunsaturated fatty acids (PUFA) on development of acute inflammation in rats has been studied. During 4 weeks male Wistar rats (initial weight 140-150 g) were on feed containing as lipid component 6% butter and 3% fish oil obtained from Sardinops sagax melanosticta (n3 PUFA-diet). The development of paw oedema induced by subplantar injection of dextran or carrageenan inhibited when the animals were on diet where prevailed n3 PUFA. In contrast, the state of paw oedema, caused by intraperitoneal administration of egg white was similarly high in rats given both n6 and n3 PUFA.</p>","PeriodicalId":18920,"journal":{"name":"Nauchnye doklady vysshei shkoly. Biologicheskie nauki","volume":" 3","pages":"103-8"},"PeriodicalIF":0.0000,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The role of polyene fatty acids in the development of acute inflammation in rats].\",\"authors\":\"O I Kirillov, N A Gubar', O V Petrukhin\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effect of n6 and n3 polyunsaturated fatty acids (PUFA) on development of acute inflammation in rats has been studied. During 4 weeks male Wistar rats (initial weight 140-150 g) were on feed containing as lipid component 6% butter and 3% fish oil obtained from Sardinops sagax melanosticta (n3 PUFA-diet). The development of paw oedema induced by subplantar injection of dextran or carrageenan inhibited when the animals were on diet where prevailed n3 PUFA. In contrast, the state of paw oedema, caused by intraperitoneal administration of egg white was similarly high in rats given both n6 and n3 PUFA.</p>\",\"PeriodicalId\":18920,\"journal\":{\"name\":\"Nauchnye doklady vysshei shkoly. Biologicheskie nauki\",\"volume\":\" 3\",\"pages\":\"103-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nauchnye doklady vysshei shkoly. Biologicheskie nauki\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nauchnye doklady vysshei shkoly. Biologicheskie nauki","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[The role of polyene fatty acids in the development of acute inflammation in rats].
The effect of n6 and n3 polyunsaturated fatty acids (PUFA) on development of acute inflammation in rats has been studied. During 4 weeks male Wistar rats (initial weight 140-150 g) were on feed containing as lipid component 6% butter and 3% fish oil obtained from Sardinops sagax melanosticta (n3 PUFA-diet). The development of paw oedema induced by subplantar injection of dextran or carrageenan inhibited when the animals were on diet where prevailed n3 PUFA. In contrast, the state of paw oedema, caused by intraperitoneal administration of egg white was similarly high in rats given both n6 and n3 PUFA.
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