The Role of mRNA Transporter in Human Cancer

Abnormal mRNA export causes many human diseases, including genetic diseases and tumorigenesis. However, the underlying mechanism was not well understood. In this study, we explored the roles of nuclear export factor2 (NXF2) in the development of hepatocellular carcinoma (HCC). We analyzed the expression level of NXF2 in HCC tissue and found down-regulation of NXF2 in HCC. Then we overexpressed NXF2 in HCC cell Huh-7 and found overexpression of NXF2 causes the down-regulation of migration and invasion in Huh-7 cells. Our results demonstrated loss-of-function of NXF2 in HCC clinical samples and the role of NXF2 in HCC tumorigenesis. Finally, we used Ingenuity Pathway Analysis (IPA) to evaluate the molecular interactions and pathway which were regulated by NXF2.