斯里兰卡成人T细胞淋巴瘤/白血病伴肾浸润1例

Somawardana Uabp, Gunasinghe R, S. S, Pieris Dc
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摘要

成人T细胞白血病/淋巴瘤(ATLL)是一种罕见的与人类T细胞嗜淋巴病毒-1 (HTLV1)相关的T细胞淋巴增生性疾病,在世界某些地区流行,因此具有独特的人口分布。到目前为止,斯里兰卡没有报告ATLL病例,因此这是第一例报告病例。肾实质浸润在ATLL中是非常罕见的。由于该病罕见,缺乏循证标准治疗方案。ATLL患者的预后很差,尤其是复发和难治性患者。在这里,我们报告一例ATLL伴肾脏受累,最初对联合化疗有反应,但后来退化为顽固性疾病,对联合免疫治疗和抗病毒治疗反应不佳。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Adult T Cell Lymphoma/Leukaemia with Renal Infiltration: A Case Report from Sri Lanka
Adult T Cell Leukaemia/Lymphoma (ATLL) is a rare T cell lymphoproliferative disease associated with Human T Cell Lym-photropic Virus-1 (HTLV1) endemic in some parts of the world and therefore has a distinct demographic distribution. There are no cases of ATLL reported in Sri Lanka thus far hence this is the first reported case. Renal parenchymal infiltration in ATLL is ex - tremely rare. Due to the rarity of the disease, evidence-based standard therapeutic options are lacking. The outcome of patients with ATLL is poor, particularly in the relapsed and refractory settings. Here we report a case of ATLL with renal involvement that initially responded to combined chemotherapy but later regressed to refractory disease with poor response to combined immunotherapy and antiviral therapy.
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