抗癌联合治疗的控制理论方法

2011 16th International Conference on Methods & Models in Automation & Robotics Pub Date : 2011-09-29 DOI:10.1109/MMAR.2011.6031364

A. Świerniak

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引用次数: 1

摘要

提出并分析了一种抗血管生成治疗与化疗相结合的模型。该模型是一个改进的Hahnfeldt模型，分析有两个目的:首先检查模型平衡点的稳定性，寻找恒剂量和周期治疗下导致肿瘤根除的条件，然后提出一个优化问题并给出其解的必要条件。我们讨论了模型的修改，使更现实地描述治疗效果。

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Control theoretic approach to combined anticancer therapies

A model of a combination of antiangiogenic treatment and chemotherapy is proposed and analyzed. The model is a modified Hahnfeldt model and the analysis has two goals: first of all we check stability of the equilibrium point of the model to find conditions leading to tumour eradication for constant dosing and periodic treatment then we propose an optimization problem and give necessary conditions of its solution. We discuss modifications of the model which enable more realistic description of treatment effects.

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2011 16th International Conference on Methods & Models in Automation & Robotics

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