融合酶及多肽对融合蛋白影响的研究进展

Chunling Ma, Fang Chen, Li Wang
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引用次数: 0

摘要

融合酶是指由两个或两个以上独立的酶或结构域组成的综合性酶结合体。它主要通过两种或两种以上酶的连接获得,在很大程度上保留了几个结构域的功能,是一种高效的蛋白质结合体。近年来,随着融合蛋白技术的发展,对融合酶功能的研究成为一个热点。科学家们认为,有必要对带有连接体的融合蛋白进行自然进化。在构建融合酶的过程中,引入连接子可以避免蛋白质折叠和催化过程中不同结构域的干扰,从而实现融合酶的高效表达。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research Progress of Fusion Enzyme and the Effect of Peptide on Fusion Protein
Fusion enzyme refers to a comprehensive enzyme binding body composed of two or more independent enzymes or domains. It is mainly obtained through the connection of two or more enzymes, which largely retains the function of several domains and is an efficient protein binding body. Recently, with the development of fusion protein technology, the research on the function of fusion enzyme has become a hot spot. Scientists believe that there is a need for the natural evolution of fusion proteins with linkers. In the process of building fusion enzymes, the introduction of linkers can avoid the interference of different domains in the process of protein folding and catalysis, so as to achieve the efficient expression of fusion enzyme.
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